Israeli scientist develops new slimming drug

It's no secret that obesity statistics are on the rise, and along with them the likelihood of many more people developing heart disease and diabetes. And while the late Anna Nicole Smith helped to popularize the slimming pills in America, these pills are known for having side effects that can wreak havoc with one's health.

In response to this dilemma, Israeli researcher Dr. Nir Barak has developed what could be a weight-loss wonder drug. Working with drug company Obecure, Barak has developed a new formulation called Histalean which is based on betahistine, an approved drug marketed worldwide for the treatment of vertigo. Betahistine has been available to health authorities for over 30 years and is therefore already FDA-approved.

Histalean has been found to quell the desire to consume fatty foods, particularly in women under the age of 50. The pill works by activating chemical agents that reduce appetite. The most recent double-blind placebo-controlled study included 281patients, men and women aged 18-65, with a BMI ranging from 30 to 40. This study revealed the effects of gender and age on the pill's response.


Now, says Obecure CEO Dr. Yaffa Beck, studies of the drug will focus primarily on women under 50, since this approach seems to work best due to the presence of estrogen.


Barak is a physician in Beilinson Hospital in Petah Tikva and an instructor at Tel Aviv University's Sackler School of Medicine. While one of Barak's areas of expertise is internal medicine, he is also a US certified expert in clinical nutrition, which he practiced for two years in the University of Chicago Hospital.

"I treat people with obesity, and I also treat people who can't eat anything and rely on intravenous feedings," says Barak. "I see both ends of the spectrum."

Barak explains that Histalean is unique in comparison to other diet pills because it focuses on the histamine system, which scientists associated for years with the immune system. It's only recently that scientists began to connect the histamine system with dietary behavior, and Histalean is the only drug of its kind that has been tested safely on humans.

Barak also cautions that while he has high hopes for Histalean, there may be a long road ahead to developing an encompassing cure for obesity, because dietary behavior is more complex than it appears on the surface.

"I don't think there's one magic pill," he says. "Every individual probably has a mixture of certain mechanisms that drive them to overeat... Once we have an arsenal of four or five drugs that work on different mechanisms, then we'll be able to start managing people more efficiently when it comes to diet."

Another area that excites Barak is the possibility that Histalean can prevent weight gain in schizophrenic patients who take the anti-psychotic drug Zyprexa. This powerful medication has significant results for schizophrenia, but also causes devastating weight gain in patients, to the extent that they may sometimes gain as much as a kilo per week. Histalean activates the same appetite-reducing chemicals which are blocked by Zyprexa, leading Barak to believe that Histalean can be developed to prevent this side effect of the drug.

"The patients are gaining weight to the degree that they develop diabetes," says Barak. "This is really a very urgent problem. Schizophrenia is among the most debilitating diseases that there are-it affects every aspect of life." Coping with this debilitating illness and obesity simultaneously can be a cruel ordeal for patients, who often opt to go off their medication or switch to an older medication which causes a Parkinson's-like disease. "They would rather have Parkinson's than be obese," comments Barak.

This chance to ease the lives of people who are already under tremendous strain is attractive to Barak. "As a physician, it's very appealing for me," he says. "There's a real need here to solve an urgent medical problem-a real problem, not a cosmetic one."

www.israel21c.org

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Do best slimming pills exist?

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We all know that a sure way to become slim is eating healthy meals and do a lot of physical activity. Slimming pills may do well in a short cut, but we have to understand how they act and what effect they are going to show.

The great variety of slimming pills is basically into two groups – prescription drugs and over the counter diet pills. Which are the best pills?

Prescription pills – moderate efficacy with strong side effects

Prescription slimming pills are clinically tested and proven to work as they claim. Let’s take Xenical – it claims to block up to 25% of fats from being absorbed by our intestines. Its action has been proved clinically so we know what we can expect.

But prescription drugs are not the best choice due to strong side effects and unnatural chemicals we have to intake into our body while taking drugs. Xenical is also clinically proven to cause oily spotting, nausea and much more…

Natural slimming pills – do they work as claimed?

The problem with natural slimming pills is that they often don’t back their claims by medical studies. You can see promises of fantastic weight loss results like “eat what you want and still lose weight” or “the weight remains permanent” and the like…

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Still, in the late years we can see the appearing of new natural slimming pills, made of safe components mixed for maximum weight loss impact. You do not need prescription to use them and if you do eat healthily and make some physical activity, you will benefit from adding slimming pills to your weight loss program.

Conclusion

If saying of best slimming pills – there is no ultimate answer. Both prescription and natural slimming pills can be your best choice depending on different factors.

If you suffer from obesity that potentially puts your health at risk and you have serious medical conditions, your best choice is prescription drugs under doctor’s control.

If you are overweight and wish to shed excess pounds than probably the best slimming pills are respectful natural slimming pills that are clinically proven and medically tested.

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Slimming pills are very popular – whatever being said of them, slimming pills do really help people lose weight and now more and more effective solutions hit on the market. Well, there may never be ideal slimming pill, but if you really want to achieve your dreams of better and healthier body – you will achieve it!

Prescription slimming pills – the only solution?

Until recent times the only medicines in the UK licensed for the treatment of obesity were sibutramine (the most known trademark Meridia) and orlistat (known under trademark Xenical). Orlistat struggles extra weight by reducing the absorption of the fat we consume with meals. Sibutramine suppresses our appetite by increasing the feeling of fullness, which is achieved by boosting serotonin levels, the chemical produced naturally in our body.

These medications have been clinically proven to help reduce excess weight, but they are prescription weight loss pills and can be prescribed by doctors only in case of obesity and resulting health problems, such as increased blood pressure, heart problems and so on. The effect of these medications increases when they are combined with dieting and exercises.

For most of the over-the-counter slimming pills that are sold in the health shops there’s usually little evidence of guaranteed weight loss. Clinical studies may also be held for over-the-counter slimming pills, but the research evidence is usually occasional, as those studies aren’t repeated. Some of over-the-counter slimming pills provide us with insufficient data on components used and the principles of pills’ work.

Slimming pills that promise you fast and steady weight loss without changing your eating habits won’t probably work as they claimed. Eating as we always do and taking slimming pills may hardly bring us satisfactory results, as compared to combining natural weight loss pills and healthy dieting, which is always the shortest way to real weight loss progress. Basically it’s not up to slimming pills itself how much weigh loss progress we are going to make, it’s always the matter of changing the whole our lifestyle.

Some slimming pills are likely to be harmful in case you have certain health conditions or taking other medication. Depending on the components, some slimming pills may interfere with prescribed medication, which is not good for our health also.

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